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What Types of Birth Defects in Children Have Been Associated With Zofran Usage?

What types of birth defects in children have been associated with Zofran usage? Recently, the correlation between mothers taking Zofran and their children being born with birth defects has grown more conspicuous. Here are some of the most common birth defects currently associated with Zofran:

  • Cleft Palate: This condition occurs when the roof of the mouth does not completely form, and the two skull plates that are supposed to fuse to form the hard palate do not do so. There are complete and incomplete forms of these conditions, but both are serious. They both result in a hole between the nose and mouth that can cause extraordinary nasal and articulation issues.
  • Cleft Lip: Cleft lip conditions closely resemble those of cleft palates. This condition occurs when the lip does not properly form either because of an underlying genetic abnormality or because of an isolated trigger. These are more common than palate problems and, after surgery to fuse the lip together, require minimal care or attention. Left untreated, however, this can cause extreme eating, speaking, and related social and psychosocial problems.
  • Heart Abnormalities: Several heart abnormalities in children have been associated with the use of Zofran by their mothers. One of the most serious and recurring is Atrial Septal Defect (also known as "hole in the heart" syndrome). This occurs when a hole in the upper two chambers of the heart allows blood to pass back and forth. Another defect children experience is Ventricular Septal Defect: a leak in the bottom two chambers of the heart that allows blood to leak between the two. While the latter is less common, both can lead to life-threatening medical issues. Finally, children with mothers who were prescribed Zofran have experienced heart murmurs.

So far, studies have only conclusively shown a correlation between Zofran and these birth defects. However, the association is conspicuous as children born to mothers prescribed this medication exhibit these conditions at a rate twice that of mothers that do not take it. Also, these are not minor or small studies; the below represents significant and scholarly work:

Finally, and maybe most troubling, Zofran can transfer from the mother to the child via the placenta up to the first three months following conception.

For additional information see the following pages:

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